M/F PhD candidate in bioproduction of stem cell derived extracellular vesicles

Descrizione

M/F PhD candidate in bioproduction of stem cell derived extracellular vesicles Sintesi in italiano (traduzione automatica): L'unità multidisciplinare NABI, situata nel campus di Saint Germain dell'Università di Parigi Cité, cerca un candidato per un dottorato di ricerca nella bioproduzione di vescicole extracellulari derivate da cellule staminali. Il candidato entrerà a far parte del team 'Nanobiotherapies' e lavorerà su un progetto finanziato che mira a sviluppare nuove metodologie per la bioproduzione ad alta capacità e rendimento di vescicole extracellulari. Le mansioni principali includono la valutazione delle firme biofisiche e biochimiche delle vescicole e delle loro proprietà terapeutiche in modelli in vitro e in vivo. È richiesta una laurea in biologia, biotecnologie o un campo correlato. Il lavoro si svolgerà in un ambiente altamente collaborativo, integrando fisica, ingegneria e biologia cellulare. The new multidisciplinary NABI unit (Nanomedicine, Extracellular Biology, Integratoma and Innovations in Health), on the Saint Germain Campus of the University of Paris Cité (45 rue des Saints Pères, 75006 Paris) was created on January 1, 2025 and brings together about 70 physicists, biologists, pharmacists, engineers and doctors, including about thirty permanent staff, under the supervision of the CNRS, of INSERM and Université Paris Cité. NABI's scientific objectives are to develop new therapies based on biological (extracellular vesicles) or synthetic (activatable metal nanoparticles) nano-objects for the delivery of personalized therapies for difficult-to-treat pathologies. TThe study of nanoobjects in biological fluids requires transdisciplinary approaches (physics, engineering, cellular and molecular biology, immunology, etc.) up to clinical practice and dedicated technical and analytical resources (super-resolution microscopy, nanoprobes, microfluidics, etc.) as well as a systematic multimodal and multiscale exploration whose analysis uses AI. These innovative methodologies are developed within NABI and in the industrial integrator IVETh, a technology hub dedicated to the characterization, bioproduction and engineering of extracellular vesicles and nanovectors for diagnosis and personalized therapies. The PhD student will join the multidisciplinary "Nanobiotherapies" team as part of the Sesame PIA Filière project funded by the BPI and the Region Ile de France. The candidate will propose new methods for high-throughput and high-yield bioproduction of extracellular vesicles from stem cells conditioned by different stimuli. He/she will evaluate, based on a multimodal characterization, their biophysical and biochemical signatures, as well as their functional and therapeutic properties, in particular in in vitro and in vivo models of tissue repair. Annuncio in inglese. Fonte: Euraxess (Commissione europea).