R1 First Stage - Predoctoral Researcher (Circadian Rhythms and Ageing Laboratory)

Descrizione

R1 First Stage - Predoctoral Researcher (Circadian Rhythms and Ageing Laboratory) Sintesi in italiano (traduzione automatica): Il laboratorio di Ritmi Circadiani e Invecchiamento cerca un Ricercatore pre-dottorale per un progetto finanziato dal Consiglio Europeo della Ricerca. La sede è in un'organizzazione internazionale e il ruolo prevede la progettazione, esecuzione e ottimizzazione di esperimenti sui ritmi circadiani e il loro impatto sul cancro in relazione all'invecchiamento. I candidati dovranno analizzare i dati, preparare presentazioni e redigere rapporti scientifici. È richiesta una laurea in Biologia, Biotecnologie o un campo correlato. Il candidato lavorerà a stretto contatto con collaboratori bioinformatici e clinici per avanzare nel progetto, contribuendo a una comprensione innovativa dell'interazione tra invecchiamento e malattie legate all'età. The earth’s daily rotation causes profound, yet repetitive, changes to environmental conditions. In response, species from prokaryotes to humans have evolved circadian clocks to drive anticipatory daily rhythms in biological processes ranging in magnitude from DNA replication to sleep-wake cycles. However, cellular, tissue and systemic circadian rhythms exhibit a generalised decay during the ageing process that may contribute to the development of aged-related diseases and onset of frailty. In the Circadian Rhythms and Ageing laboratory , we aim to determine why this detrimental decay occurs and ask how we can correct or exploit these changes. To do so, we apply cutting edge in vivo, in vitro and in silico tools to provide unique, clinically relevant perspectives on the ageing of the bodies circadian system. Age is cancers primary risk factor and a significant determinant of how this often-devastating disease presents and progresses. Concurrently, circadian inputs from the body are known to drive daily rhythms in tumour microenvironment composition, metastasis seeding and treatment response, whilst disruption of physiological circadian rhythms is itself an established tumour promoter. However, whether the ageing of the bodies circadian system reshapes the initiation and development of cancer remains unknown. To address this question, the selected candidates develop a European Research Council-funded project that asks how ageing of the circadian system impinges upon the biology of cancer. In particular, this project will look to address three key questions: Does ageing of the body and its circadian rhythm system change the tumourigenic potency of circadian rhythm disruption? Are the circadian rhythms of an established tumour altered by ageing of the host and its circadian system? If cancer circadian biology is rewired by ageing, can we identify where this change originates from? To tackle these questions, the selected candidates will combine cutting-edge models of ageing and cancer with targeted circadian rhythm disruption and circadian-omics to reveal the as-yet-uncharacterised interaction between an emerging hallmark of ageing, circadian rhythm decay, and the most common of age-related diseases, cancer. If successful, the knowledge generated by this project will provide a roadmap for identifying interventions that diminish cancer risk later in life, and contribute to refining and expanding the burgeoning field of cancer chronotherapy. Main responsibilities and duties: Design, perform and optimise experiments related to the project. Analyse and interpret resulting data sets. Prepare and deliver presentations of project data for internal and external audiences. Write and edit scientific reports and research papers. Work together with bioinformatic and clinical collaborators to dynamise and advance the project. Annuncio in inglese. Fonte: Euraxess (Commissione europea).