Postdoctorant/Postdoctorant (M/F) in Molecular Biology

Descrizione

Postdoctorant/Postdoctorant (M/F) in Molecular Biology Sintesi in italiano (traduzione automatica): L'organizzazione cerca un ricercatore post-dottorato in biologia molecolare per partecipare a un progetto presso l'Institut de Génomique Fonctionnelle de Lyon. Il candidato selezionato si occuperà di studiare i meccanismi molecolari e cellulari che controllano la diversità muscolare durante lo sviluppo, utilizzando modelli di Drosophila e/o topi. Le mansioni principali includono esperimenti di biologia dello sviluppo e genetica, analisi di sequenziamento a singola cellula, e l'uso di approcci di transcriptomica spaziale. È richiesta una laurea in biologia o un campo correlato, oltre a competenze in bioinformatica e microscopia avanzata. Il lavoro si svolgerà in un ambiente scientifico internazionale e interdisciplinare, con opportunità di collaborazione e pubblicazione di articoli scientifici. The successful candidate will participate in a project aimed at understanding the molecular and cellular mechanisms that control the generation of muscle diversity during development. The project will combine approaches in developmental biology, genetics, single-cell and spatial transcriptomics, advanced imaging, and bioinformatics. The main objective will be to identify the gene networks involved in muscle morphogenesis, reconstruct their organization in space and time, and test their function in vivo using Drosophila and/or mouse models. The successful candidate will be expected to: • Perform developmental biology and genetics experiments in Drosophila and/or mouse models. • Prepare and analyze samples for single-cell and/or single-nucleus sequencing approaches. • Participate in the development and use of 3D spatial transcriptomics approaches. • Analyze gene expression and regulatory networks associated with muscle diversification. • Reconstruct the spatial and temporal organization of the cell populations involved in muscle formation. • Use genetic tools to selectively modify the genotype of myoblasts or muscles during development. • Study the consequences of these manipulations on muscle architecture using advanced microscopy. • Contribute to the analysis of locomotor phenotypes using behavioral assays. • Participate in the bioinformatic analysis of the generated data, in collaboration with other team members. • Present results at team meetings, seminars, and conferences. • Contribute to the writing of scientific articles. The work will be carried out at the Institut de Génomique Fonctionnelle de Lyon, at the École Normale Supérieure de Lyon, on the Lyon Gerland campus. The IGFL offers an international and interdisciplinary scientific environment at the interface of evolution, development, functional genomics, integrative physiology, bioinformatics, and genetics. The successful candidate will join a team studying the mechanisms that control muscle formation, identity, and function during development. They will benefit from a stimulating environment, state-of-the-art equipment, and access to technological platforms for single-cell sequencing, spatial transcriptomics, and advanced microscopy, including confocal microscopy and 3D STED microscopy. The project is part of a collaborative framework combining experimental and computational approaches. The successful candidate will interact with biologists, bioinformaticians, engineers, and imaging specialists. Annuncio in inglese. Fonte: Euraxess (Commissione europea).