Postdoc Position in Computational Antigen Discovery

Descrizione

Postdoc Position in Computational Antigen Discovery Sintesi in italiano (traduzione automatica): L'Università di Utrecht cerca un Ricercatore post-dottorato altamente motivato per unirsi a un team multidisciplinare specializzato nella scoperta di antigeni per immunoterapie. Il candidato selezionato lavorerà sotto la supervisione del dottor Marino, sviluppando e applicando flussi di lavoro bioinformatici all'avanguardia per l'identificazione e la validazione degli antigeni. Le principali mansioni includono l'analisi e la visualizzazione dei dati per progetti di proteogenomica, l'organizzazione di dati multi-omici e l'implementazione di tecniche AI/ML. È richiesta una laurea in Biologia, Bioinformatica o un campo correlato. Il ruolo prevede anche collaborazioni con istituzioni accademiche e industriali, contribuendo a pubblicazioni scientifiche e presentazioni. Questa posizione offre l'opportunità di sviluppare pipeline innovative e di ampliare la rete professionale del candidato. At Utrecht University, we have built a specialized team focusing on the discovery of previously unidentified antigens for immunotherapies through mass spectrometry (MS)-based proteomics and immunopeptidomics. We now seek a highly motivated and experienced Postdoctoral Researcher to join our multidisciplinary research team. Your job As a Postdoctoral Researcher in the group of dr Marino , you will play a central role in advancing the group's research through the development and application of state-of-the-art bioinformatics workflows for antigen identification, quantification, and validation. You will support the whole team in data analysis and visualization for different proteogenomics projects. You will organize and merge multi-omics data (in collaboration with our partners at Princess Maxima Center) using AI/ML techniques, implement antigen data analysis and discovery processes, and contribute to the maintenance of data infrastructure in collaboration with internal team members and other multidisciplinary teams. In this role, you will also take the lead in developing new ideas and initiatives that advance the group’s research. This position will significantly impact the team by developing innovative bioinformatics pipelines, and by pinpointing and measuring the most immunogenic antigens for integration into vaccine-based therapies aimed at improving outcomes for patients with cancer. Finally, you will be involved in many different multicentered and multidisciplinary collaborations, with both industry as well as academia and medical institutes. This will increase your exposure and expand your own professional network, supporting your future scientific career. Key Responsibilities Develop and maintain scalable pipelines for mass spectrometry (MS)-based proteomics and immunopeptidomics data analysis. Design integrative frameworks combining genomics, transcriptomics, ribosomal profiling and proteomics datasets. Develop and maintain high-quality pipelines for processing and visualizing large-scale proteogenomics, MS-based immunopeptidomics/proteomics data. Ensure reproducibility and scalability of workflows using modern workflow tools (es. Nextflow, Snakemake, CWL etc.). Contribute to scientific publications, grant writing, and presentations. Collaborate with internal/external groups to develop new analysis pipelines tailored to immunopeptidomics experiments. Stay at the forefront of scientific advances in mass spectrometry-based immunopeptidomics/proteomics including software and new methodologies. Annuncio in inglese. Fonte: Euraxess (Commissione europea).