Postdoc position - Unraveling Immune Checkpoint Inhibitor Toxicity and Efficacy

Descrizione

Postdoc position - Unraveling Immune Checkpoint Inhibitor Toxicity and Efficacy Sintesi in italiano (traduzione automatica): L'organizzazione internazionale offre una posizione di ricercatore post-dottorato per studiare la tossicità e l'efficacia degli inibitori dei checkpoint immunitari (ICI) presso il Dipartimento di Oncologia Medica, sotto la supervisione del Prof. Karijn Suijkerbuijk. Il candidato selezionato avrà accesso a una biobanca unica con campioni da oltre 600 pazienti trattati con ICI, permettendo di indagare i meccanismi alla base della tossicità e della resistenza al trattamento. Le mansioni principali includono la pianificazione e documentazione di esperimenti, analisi di dati molecolari e clinici, presentazione dei risultati e supervisione di ricercatori junior e dottorandi. È richiesta una laurea di dottorato in ambito biomedico o affini, con esperienza in ricerca clinica e immunoterapia. Immune checkpoint inhibitors (ICIs) have been the largest breakthrough in oncology in the last decade. However, they are effective for only a minority of patients and can cause severe immune-mediated toxicities . Within the UNICIT biobank, we have collected sequential blood, feces, and tissue biopsy samples from more than 600 patients treated with ICIs. This unique resource allows you to investigate the mechanisms behind ICI toxicity and treatment resistance and identify factors that could improve patient outcomes. As a postdoctoral researcher, you will join the research group of Prof. Karijn Suijkerbuijk at the Department of Medical Oncology. The group focuses on clinical and translational research in melanoma and cancer immunotherapy, with a strong emphasis on immune checkpoint inhibitors. You will conduct a research project on ICI toxicity and resistance under the supervision of Prof. Karijn Suijkerbuijk. Alongside your own research, you will contribute to collaborative projects, supervise junior researchers and PhD candidates, and help develop new research proposals to secure future funding. Key responsibilities As a postdoctoral researcher, you will: Plan, perform, and document experiments. Analyze and interpret molecular and clinical data. Present your findings in oral and written presentations. Collaborate closely with researchers within and outside the department. Supervise junior researchers and/or PhD candidates working on related projects. Write grant proposals. Annuncio in inglese. Fonte: Euraxess (Commissione europea).