M/F Post doctoral researcher in multimodal charactization of Gram+ bacteria's extracellulair vesicles for therapeutic applications to treat inflammation

Descrizione

M/F Post doctoral researcher in multimodal charactization of Gram+ bacteria's extracellulair vesicles for therapeutic applications to treat inflammation Sintesi in italiano (traduzione automatica): L'organizzazione NABI, situata nel campus di Saint Germain dell'Université Paris Cité, cerca un ricercatore post-dottorato per caratterizzare le vescicole extracellulari (EVs) di batteri Gram+ per applicazioni terapeutiche anti-infiammatorie. Il candidato lavorerà in un team multidisciplinare, utilizzando tecniche avanzate come la microscopia ottica, l'analisi delle immagini e la microfluidica. Sarà coinvolto nello sviluppo di nuove terapie basate su nano-oggetti biologici e sintetici. È richiesta una laurea in biologia, ingegneria o un campo correlato, con competenze in analisi multimodale e approcci transdisciplinari. Il progetto è parte del PEPR BacterEBBooster, focalizzato su vescicole extracellulari di origine batterica. The cadidate will integrate an ambitious multidisciplinary team aiming to characterize using pluridisciplinary, multimodal and multiscale techniques (including physical characterization: size and concentration, phenotypic, biomolecular fingerprint through Raman spectroscopy, nanoscopy etc.) EVs from Gram+ bacteria for anti-inflammatory therapeutic applications. - Advanced optical microscopy (nanoscopy) - Image acquisition and analysis - Microfluidics - Fluorescent labeling protocol - Multimodal characterization of extracellular vesicles - Modeling and AI for image analysis The new multidisciplinary unit NABI (Nanomedicine, Extracellular Biology, Integratome and Health Innovations), located on the Saint Germain Campus of Université Paris Cité (45 rue des Saints Pères, 75006 Paris), was established on January 1, 2025. It brings together around 70 collaborators—including physicists, biologists, pharmacists, engineers, and physicians—of which about thirty are permanent staff, under the joint supervision of CNRS, INSERM, and Université Paris Cité. NABI's scientific objectives are to develop new therapies based on biological nano-objects (extracellular vesicles) or synthetic nano-objects (activatable metallic nanoparticles) for the delivery of personalized treatments for hard-to-treat diseases. Studying nano-objects in biological fluids requires transdisciplinary approaches (physics, engineering, cell and molecular biology, immunology, etc.) extending all the way to clinical practice, as well as dedicated technical and analytical resources (super-resolution microscopy, nanosensors, microfluidics, etc.), combined with systematic multimodal and multiscale exploration supported by AI-driven analysis. These innovative methodologies are developed within NABI and in partnership with the industrial integrator IVETh, a technology hub dedicated to the characterization, bioproduction, and engineering of extracellular vesicles and nanovectors for diagnostics and personalized therapies. The agent will join the multidisciplinary “Nanobiotherapies” team as part of PEPR BacterEBBooster project focusing on anti-inflammatory extracellular vesicles from bacterial origin. Annuncio in inglese. Fonte: Euraxess (Commissione europea).