Postdoc in cryo-electron microscopy and structural virology - M/F

Descrizione

Postdoc in cryo-electron microscopy and structural virology - M/F Sintesi in italiano (traduzione automatica): Il ruolo di Ricercatore post-dottorato in microscopia crio-elettronica e virologia strutturale è offerto dall'Istituto di Biologia Strutturale (IBS) situato nel Grenoble Science Park. Il candidato si concentrerà sull'analisi dei meccanismi di replicazione del Virus Respiratorio Sinciziale (RSV) utilizzando tecniche avanzate come la tomografia crio-elettronica e la microscopia crio-elettronica a singola particella. Le mansioni principali includono la preparazione dei campioni, l'ottimizzazione delle tecniche di crio-EM, l'analisi delle immagini 3D e la caratterizzazione biochimica e biofisica dei complessi ribonucleoproteici del RSV. È richiesta una laurea in biologia, biotecnologie o discipline affini, e il candidato lavorerà in un ambiente internazionale con accesso a infrastrutture all'avanguardia. Respiratory Syncytial Virus RSV is a major public threat, particularly dangerous for children and the elderly, with no therapeutic options available for the vast majority of the population. This position aims at uncovering the mechanisms of RSV replication in the infected cell by cryo-electron tomography and single particle cryo-electron microscopy. Sample preparation, optimisation, cryo-EM, cryo-CLEM, cryo-FIB milling and cryo-ET, 3D image analysis and, where appropriate, biochemical and biophysical characterisation of the RSV ribonucleoprotein complexes to understand the mechanisms involved. Located on the Grenoble Science Park (ESRF/ILL/EMBL/IBS), the Institute of Structural Biology (IBS) is a national and international player in the field of integrated structural biology. The IBS is a research institute, a technical platform, a host site and a scientific training center affiliated to the Université Grenoble-Alpes, the CNRS and the CEA. It currently employs about 320 scientists, including numerous students and post-docs from all over the world, and benefits from state-of-the-art infrastructure and equipment in cellular and molecular biology, biochemistry, biophysics and structural biology. The IBS is one of the founders of the Partnership for Structural Biology (PSB) with prestigious European institutes: the European Synchrotron Radiation Facility (ESRF), the ILL neutron scattering facilities, and the European Molecular Biology Laboratory (EMBL) Grenoble outstation, all located at the same campus, offering a strong international environment. As a joint research unit (CEA-CNRS-UGA), the IBS is composed of 20 research groups, each of which proposes a multi-disciplinary approach, at the frontiers of biology, physics and chemistry. Within the IBS, the candidate will join the https://www.ibs.fr/en/research/assembly-dynamics-and-reactivity/microsc… group focused on imaging macromolecular complexes and cells with the goal of gaining structural insights that would yield functional understanding of cellular processes, and with a strong interest in nanoscale exploration of the multiplication of the human RSV. Annuncio in inglese. Fonte: Euraxess (Commissione europea).