PHD GSO 035-26 Fully Funded PhD Scholarship in Endocrine resistance in ER-positive breast cancer [CMNHS/ School of Medicine / Discipline of Pathology / LAMBE Institute]

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PHD GSO 035-26 Fully Funded PhD Scholarship in Endocrine resistance in ER-positive breast cancer [CMNHS/ School of Medicine / Discipline of Pathology / LAMBE Institute] Sintesi in italiano (traduzione automatica): L'Università di Galway offre una borsa di studio per un dottorato di ricerca completamente finanziato, che inizierà nell'ottobre 2026, presso il LAMBE Institute della Scuola di Medicina. Il progetto di ricerca si concentra sulla resistenza endocrina nel cancro al seno ER-positivo, esplorando i geni regolati dalla risposta proteica non funzionale (UPR) come potenziali bersagli terapeutici. I candidati devono possedere una laurea in Biologia del Cancro, Biologia Molecolare, Biochimica, Scienze Biomediche o discipline correlate, con una buona preparazione accademica e esperienza in laboratorio. È richiesta una forte motivazione, capacità organizzative e competenze comunicative elevate in inglese. La borsa prevede un'indennità annuale di €25.000 e copre le tasse universitarie di €5.750. La scadenza per le candidature è il 31 luglio 2026. Applications are invited from suitably qualified candidates for a full-time funded PhD scholarship starting in October 2026 affiliated to the [ CMNHS/ School of Medicine / Discipline of Pathology / LAMBE Institute ] at the University of Galway. University of Galway Located in the vibrant cultural city of Galway in the west of Ireland, the University of Galway has a distinguished reputation for teaching and research excellence For information on moving to Ireland please see www.euraxess.ie Detailed Project Description: Endocrine therapy (ET), including tamoxifen, letrozole and fulvestrant, is central to the treatment of ER-positive Breast Cancer and has significantly reduced recurrence and mortality. However, despite initial clinical benefit, up to 40% of patients develop endocrine resistance, leading to relapse and disease progression. We hypothesise that adaptive UPR activation promotes endocrine resistance in ER-positive breast cancer by sustaining ER-dependent and ER-independent survival signalling; and modulation of key UPR pathways mediators will restore sensitivity to endocrine therapy. This 4-year funded PhD project will investigate UPR regulated genes as a novel regulator of endocrine resistance in ER-positive breast cancer and potential therapeutic target for improved outcomes. Living allowance (Stipend): €25,000 per annum, [tax-exempt scholarship award] University fees : €5,750 (covered by scholarship) Start date : Autumn 2026 Academic Entry Requirements: We are looking for a highly motivated, enthusiastic, and ambitious applicant with curiosity and passion for science. Candidates must demonstrate 1) an understanding of the molecular basis of cancer formation, 2) Insight into clinical issues related to cancer diagnosis, prognosis and treatment and 3) Evidence of having undertaken a research project in a cancer-related laboratory. Candidates must have a good undergraduate degree (First Class Honours), and master’s degree in Cancer Biology, Molecular Biology, Biochemistry, Biomedical science or related discipline. Knowledge of cancer biology or experience with cell culture, biological assays, cloning, flow cytometry or in vivo work will be an advantage. The successful applicant will be highly self-motivated, possessing the organizational skills, resilience and drive necessary to manage an independent research project and produce high-quality impactful academic research; they must have excellent communication skills with a very high level of written and spoken English. To Apply for the Scholarship: A statement (max 1000 words) which includes 1) Your motivation for choosing this course and highlighting the reasons for your suitability 2) Something about you and your life experience beyond your academic studies 3) Where you saw the studentship advertised. Evidence of competence in English your 2-page CV summarising your qualifications and relevant experience. Please also include the contact details of Two referees willing to give you a reference Contact Name: Dr Sanjeev Gupta Contact Email: sanjeev.gupta@universityofgalway.ie Application Deadline: 31/07/2026 at 17:00 Primary Supervisor name : Sanjeev Gupta Annuncio in inglese. Fonte: Euraxess (Commissione europea).