Postdoctoral position on the Synthesis and Study of Surface Reactivity of Gold-Carbon Nanostructures for Radiosensitization (M/F)

Descrizione

Postdoctoral position on the Synthesis and Study of Surface Reactivity of Gold-Carbon Nanostructures for Radiosensitization (M/F) Sintesi in italiano (traduzione automatica): L'ente offre una posizione post-dottorale per la sintesi e lo studio della reattività superficiale di nanostrutture ibridi oro-carbonio per la radiosensibilizzazione. La sede è presso l'Institut de Chimie Physique, dove il ricercatore lavorerà nel progetto EXPLORE RAINHET. Le mansioni principali includono la progettazione e sintesi di nanostrutture, la funzionalizzazione superficiale, la caratterizzazione analitica e l'indagine della reattività radicalica sotto irradiazione gamma. È richiesta una laurea in chimica o un campo correlato, con competenze in chimica fisica e nanostrutture. Il candidato collaborerà con gruppi di ricerca specializzati in sintesi e caratterizzazione di nanostrutture e generazione di radicali. - Design and synthesis of a new family of hybrid gold–carbon nanostructures, in which carbon nanostructures act as supports for ultrasmall gold nanoparticles. Different synthetic approaches will be explored, including (solvo)thermal, radiolytic and/or sonochemical methods. - Selective surface functionalization of both components to produce nanostructures bearing independently controlled surface chemistries. Gold nanoparticles will be functionalized to maximize radiation-induced radical production, while the carbon surface will be modified either to prevent the adsorption of a biological ligand corona—which is known to reduce radical enhancement—or to introduce targeting ligands for future in vivo applications. - Comprehensive characterization of the synthesized nanostructures using complementary analytical techniques, including FTIR, UV–Visible spectroscopy, SFG spectroscopy, DLS, zeta potential measurements and HR-TEM. - Investigation of the radical reactivity of the nanostructures under gamma irradiation (panoramic ⁶⁰Co source) using fluorescence spectroscopy to quantify radical production. The postdoctoral researcher will be a member of the EXPLORE RAINHET project, which brings together researchers from ICP with complementary areas of expertise. Their role will be to advance the project's "Synthesis and Reactivity" research axis. The candidate will conduct research jointly within the CPSysBio (Physical Chemistry of Biological Systems) and TEMiC (Electron Transfer in Condensed Matter) research groups at the Institut de Chimie Physique. These two groups possess complementary expertise in nanostructure synthesis and characterization, radical generation under irradiation, and the evaluation of photo- and electrocatalytic properties. Annuncio in inglese. Fonte: Euraxess (Commissione europea).