Doctoral student in biomedical science with a focus on pharmaceutical analysis and biopharmaceutics in inhalation therapy

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Testo originale dell'annuncio (in inglese)

Malmö University is an innovative, urban, and internationally-oriented academic institution that, thanks to its committed and experienced staff, contributes to societal development. Here, teachers, researchers, and other employees with various competencies work together to conduct high-quality education and research. All professional categories and roles are important. You are welcome to apply for a job with us! Here you can learn more about what it's like to work at Malmö University: Work with us We are looking for A doctoral student in biomedical science at the Faculty of Health and Society. Subject area: Pharmaceutical science with specialisation in drug delivery and biophysical characterisation of biopharmaceutical products for inhalation therapy. Work duties A doctoral student shall primarily devote themselves to their own doctoral education. However, a doctoral student may, to a limited extent, work with education, other research or artistic research and administration, though not more than 20 per cent of full-time working hours (Higher Education Ordinance, Chapter 5, Section 2). BioInhale is a research project at Malmö University that has been awarded funding from the Knowledge Foundation. The project aims to promote the development of inhalation-based drug therapy by clarifying how drug molecules, from small molecules to macromolecules, interact with the lung epithelium during aerosolisation and deposition, dissolution and permeation, as well as clearance/elimination, thereby showing how regional differences in the lung govern drug distribution and disposition. Pulmonary drug administration (inhalation therapy) is being explored increasingly for the treatment of various diseases, as it shows potential to improve safety, target specificity and pharmacokinetic profile compared with conventional routes of administration. At the same time, the human airways constitute an intricate and heterogeneous structure with pronounced regional physiological variations. The airways function as a barrier between the body’s internal and external environments, enable gas exchange and perform central functions such as conditioning inhaled air, mucociliary clearance and immune signalling. The project will be carried out in close collaboration with six Swedish and international industrial partners: Emmace Consulting, Bioneer, MatTek, Inhalation Sciences, Truly Labs and Magle ChemoSwed, as well as with advice from leading pharmaceutical companies such as AstraZeneca. The collaboration with industry, universities and research infrastructures ensures access to cutting-edge expertise and advanced research resources. The project comprises two doctoral students working in parallel within the project. This position focuses on pharmaceutical analysis and biopharmaceutics in inhalation therapy. As a doctoral student, you will work at the interface between pharmaceutical science, biophysics, aerosol science and drug development. The duties include developing and characterising inhalation formulations for both small molecules and biological drugs, studying aerosol generation and deposition in the airways, and investigating drug dissolution, permeation, retention and clearance in the lung. The project also includes biophysical characterisation and experimental studies of how macromolecules interact with and are transported across the biological barriers of the lung. In addition, the work includes analysis and modelling of data to increase understanding of how regional differences in the lung affect drug distribution and pharmacokinetics. Qualifications To be admitted to doctoral studies, the applicant must meet the general and the specific eligibility requirements for the subject, and must also be subject and having the ability otherwise required to benefit from the programme. General eligibility for doctoral studies (in accordance with Chapter 7, Section 39 of the Higher Education Ordinance) is met by a person who: has been awarded a second-cycle qual Annuncio in inglese. F