Scientist in clinical nutrition/gastroenterology (ref 305593)

Descrizione

Testo originale dell'annuncio (in inglese)

A two-year 50% position as Scientist (SKO 1109) with background in clinical nutrition and/or gastroenterology is available at the Norwegian Coeliac Disease Research Centre, Institute of clinical medicine, University of Oslo. he position is funded by Coeliac UK as part of a research project that will explore whether low-level gluten exposure (i.e. levels below the current definition of gluten free diet) can cause gut inflammation and gut damage in subjects with coeliac disease. Specifically, we will in a placebo-controlled oral gluten challenge trial seek to determine whether repeat low-dose of gluten can induce immune activation and low-level gut inflammation. The project builds upon recent data from the Centre (Stamnæs et al J Clin Invest 2025 PMID 40828615) that identifies a central role for interferon gamma in the induction of gut damage and remodeling. In this project we will perform multiparameter flow-cytometry of gut biopsies collected from patients subjected to low-dose gluten challenge as well as short-term ex vivo biopsy cultures to determine the source of inflammatory cytokines and experimentally establish a mechanistic link between immune cell activation, cytokine secretion and gut inflammation and remodeling in response to dietary gluten. This project will rely on advanced cell biology methods including establishment ex vivo short-term intestinal biopsy culture followed by down-stream processing and analysis by methods such as flow cytometry, microscopy imaging and mass spectrometry-based proteomics. For more information and how to apply: https://www.jobbnorge.no/en/available-jobs/job/305593/scientist-in-clinical-nutrition-gastroenterology