Postdoc – Advanced Viral Vector Technology & Bioprocess Development

Descrizione

Testo originale dell'annuncio (in inglese)

We are seeking a highly skilled and motivated Postdoctoral Researcher with demonstrated expertise in viral vector engineering, manufacturing, downstream processing, and analytical validation. This position offers a unique opportunity to contribute to cutting-edge research in viral vector bioprocessing while working within a highly collaborative international network at the forefront of gene therapy manufacturing and process innovation. The project focuses on the development and optimization of scalable bioprocesses for viral vector production and downstream purification and concentration. The successful candidate will have extensive experience in the production, scale-up, and process engineering of retroviral vectors, including MLV-based retroviral vectors, SIV/FIV/HIV-derived lentiviral vectors , and related virus-like particles (VLPs) . Expertise in process characterization, critical quality attribute (CQA) assessment, and analytical validation is highly desirable. This role combines hands-on scientific leadership, bioprocess innovation , and strategic project coordination within the Laboratory of Molecular Virology and Gene Therapy (LMVGT), while collaborating closely with an international multidisciplinary research consortium. The position is a fully funded, full-time FTE position associated with a three year international grant cycle beginning in Q3 2026. Research and Workflow Management Skills expected: Independent design, plan and coordinate research in accordance with the projects objectives Serve as the primary liaison between LMVGT, LVVC and consortium partners and the other teams Track milestones, deliverables, and project timelines ; prepare, present and communicate project updates, directives, and scientific progress across teams Provide scientific background and feedback on results to technicians and scientific guidance to other team members Organize and coordinate inter‑ and intra‑team meetings Maintain meticulous documentation of decisions, action items, and project activities Build strong working relationships with PIs, researchers, technicians, and external collaborators Implement strategies to ensure timely completion Generate scientific proposals to resolve key technical hurdles associated with our work/studies Ensure compliance of research studies with internal project guidelines in regard to open access, data tracebillity, laboratory ethics and SOPs Assist in preparation and submission of annual scientific and financial reports Scientific Management Identify scientific and operational synergies across teams Promote knowledge exchange within the group and across consortium labs Engage with scientific staff to align goals, troubleshoot challenges, and explore collaborative opportunities Connect researchers with relevant resources, technologies, and expertise to maximize project impact Responsible for FAIR data management and data sharing according to Open Science requirements Research & Technical Skills PhD in biotechnology, biomedical sciences, bioscience engineering, or related discipline. Experience in viral vector technology, bioprocess development for rAAV and particularly retroviral vectors and virus-like particles (VLPs) Expertise in translating laboratory-scale vector production processes to robust preclinical-scale manufacturing, including optimization of upstream and downstream workflows to meet increased vector demand for in vivo animal studies Hands-on experience with CRISPR-Cas genome editing, including generation and validation of knockout (KO) lines. Expertise in base- and prime editing, endogenous gene tagging and targeted knock-in of large DNA cargos via homology-directed repair (HDR) is a strong asset Demonstrated experience with FAIR data storage and sharing (readme files, use of metadata standards, familiar with protocols.io, Zenodo, discipline specific repositories) Soft Skills Outstanding organisational and communication abilities Strong problem-solving skills, eagerness to manage mult