Call for the assignment of a research grant, with one position(s), under the project COMPETE2030-FEDER-00766600 operation n.º 16495, title Fyn-in-HD (L1206037)

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Call for the assignment of a research grant, with one position(s), under the project COMPETE2030-FEDER-00766600 operation n.º 16495, title Fyn-in-HD (L1206037) Sintesi in italiano (traduzione automatica): L'Università di Coimbra ha aperto una selezione per l'assegnazione di una borsa di ricerca nell'ambito del progetto COMPETE2030-FEDER-00766600, intitolato Fyn-in-HD, che si concentra sull'esplorazione degli interattori della chinasi Fyn nella patologia neuronale associata alla malattia di Huntington. La posizione è aperta a candidati con laurea magistrale in Neuroscienze, Biomedicina o campi affini, iscritti a un dottorato o a corsi non di laurea correlati. La borsa avrà una durata iniziale di 12 mesi, con possibilità di rinnovo, e si svolgerà presso il CNC dell'Università di Coimbra, in Portogallo. I candidati devono soddisfare requisiti legali specifici e possono includere cittadini portoghesi, di altri Stati membri dell'UE e di paesi terzi. La borsa prevede un compenso mensile di 1.359,64€. Call for Research Grant Assignment The University of Coimbra opens a call for the assignment of a research grant, with one position(s), under the project COMPETE2030-FEDER-00766600 operation n.º 16495, title Fyn-in-HD - EXPLORING FYN-MITOCHONDRIA INTERACTORS IN HUNTINGTON´S DISEASE STRIATAL NEURONAL PATHOLOGY The call is governed by this Notice of Opening, the University of Coimbra Research Grant Regulations (RBI-UC), subsidiarily by the Research Grant Regulations of the Foundation for Science and Technology (RBI-FCT), by the Research Fellow Statute (EBI), by the Norms for Grant Assignment and Management within R&D Projects, by the Code of Administrative Procedure (CPA), all in their current wording, and by other applicable national and community legislation. Procedure Reference: IT137-26-312 I - Legal admission requirements I.I - Grant Recipients: Masters enrolled in a doctoral degree, in the scientific area of of Neuroscience, Biomedicine or a related field OR Master’s degree holders, in the scientific area of Neuroscience, Biomedicine or a related field, enrolled in a non-degree-granting course I.II - The non-degree-granting course must be related to the type of activity covered by the grant. Non-degree-granting courses are defined as those referred to in subparagraph e) of paragraph 3 of Article 4 of Decree-Law No. 74/2006, in its current wording, provided that, under subparagraph e) of Article 3 of RBI-FCT, they are developed in association or cooperation between the higher education institution and one or more R&D units. I.III - Ineligible candidates: Candidates enrolled in non-degree-granting courses who have already benefited from a grant contract and who, with this grant assignment, including possible renewals, exceed a total accumulated period of two consecutive or non-consecutive years in this type of grant. Candidates who have already benefited from two research grant contracts with UC in the condition of being enrolled in a doctoral degree, regardless of whether each contract has reached the maximum legally permitted duration. I.IV - Eligible for grant assignment if meeting the requirements: a) Portuguese nationals or nationals of other EU Member States b) Nationals of third countries c) Stateless persons d) Beneficiaries of political refugee status When the work plan takes place, in whole or in part, in foreign institutions, only candidates who can prove permanent and habitual residence in Portugal at the start of the grant are eligible. II - Grant location: CNC – University of Coimbra, Portugal III- Scientific supervision/coordination of the grant: Ildete Luisa Araújo Ferreira IV - Work Plan / Goals to be achieved: The research work will focus on investigating the role of Fyn kinase on the synaptic and mitochondrial dysfunction associated with Huntington’s disease (HD), using primary striatal neuron cultures derived from YAC128 and wild-type (WT) mice. The modulation of Fyn expression through overexpression and knockdown will be performed to assess their effects on the organization and function of cortico-striatal glutamatergic synapses. Advanced fluorescence microscopy and live-cell imaging techniques will be employed to analyze dendritic spine morphology, the surface dynamics and trafficking of glutamate receptors, and intracellular Ca²¿ signaling. The work plan will also include the evaluation of local synapse-mitochondria interactions and mitochondrial function. V - Initial grant duration: 12 months V.I - Renewal Possibility: Possibily renewable VI - Funding and financial conditions of the grant VI.I - Monthly grant amount (paid by bank transfer at the end of each month): 1.359,64€ VI.II - Other financial components of the grant: NA VI.III - In addition to the above amounts, voluntary social security (SSV) is included when the grant has a duration of six months or more, corresponding to the first level, if the candidate opts for it, as well as mandatory personal accident insurance. VI.IV - Funding: