Research fellowship

Descrizione

Research fellowship Sintesi in italiano (traduzione automatica): L'i3S – Institute for Research and Innovation in Health di Porto, Portogallo, offre una borsa di ricerca per attività di R&D nel progetto 'The genetic maze of Familial Amyloid Polyneuropathy ATTRV30M: a genomic approach'. Il candidato ideale deve essere iscritto a un corso di laurea non accademico integrato in un progetto di istruzione superiore e possedere una laurea magistrale in Scienze della Vita con una media finale di almeno 18. È richiesta esperienza in ATTRv-PN e bioinformatica, in particolare nell'analisi dell'espressione genica. La borsa avrà una durata di 4 mesi, con inizio previsto il 1 settembre 2026, e un compenso mensile di €1.359,64. La posizione richiede anche competenze in analisi dei dati RNA-seq e comunicazione in portoghese e inglese. Research fellowship Reference: Fellow_BI/FCT2022/i3S/10072307/2026 i3S – Institute for Research and Innovation in Health (hereinafter i3S) is opening a call to award a grant for the development of R&D activities by Master´s enrolled in non-academic degree courses integrated into the educational project of a higher education institution, within the project “The genetic maze of Familial Amyloid Polyneuropathy ATTRV30M: a genomic approach”, ref. - 2022.01656.PTDC, financed by national funds through FCT – Fundação para a Ciência e a Tecnologia, I.P. Host Institution: i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal. Scientific Area : Neurogenetics. Project Title: “The genetic maze of Familial Amyloid Polyneuropathy ATTRV30M: a genomic approach”. Workplan: ATTRV30M amyloidosis or Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a rare autosomal dominant amyloidosis that presents as a progressive sensorimotor and autonomic polyneuropathy, due to variants in the transthyretin (TTR) gene, Val30Met (V30M) is, by far, the commonest, being associated with various clusters and present worldwide. Current consensus is in line with the notion that while each disease-causing variant sensitizes the genome to a primary clinical manifestation, additional variants in the genetic background modulate the phenotype expression. This disorder shows a large variability of age-at-onset (AO) between disease clusters and importantly, within families (19-82 yrs in Portugal). This variability suggests that genetic modifiers, either conferring protection (late-onset cases) or increasing risk (early-onset cases). In the FAPGen project, we aim to explore genetic mechanisms that may act as AO modifiers in ATTRv-PN. In this way, and taking into account the whole-genome sequencing (WGS) analyses previously carried out within the scope of this project, we aim to determine which genomic variants identified by WGS are correlated with gene expression or regulatory changes, through a whole RNA sequencing study in salivary gland biopsies from ATTRv-PN patients. Admission Requirements : Mandatory: Candidates must have completed a Master’s degree in the area of Life Sciences with a final grade average of 18 or higher; Experience in ATTRv-PN and bioinformatics, namely in gene expression analysis, is required; Candidates must be enrolled in a non-academic degree course integrated into the educational project of a higher education institution, until contract start date; Or: an honor statement of capacity to enroll in the aforementioned course until the grant is contracted; Preferential: Experience and solid knowledge in the following areas: Strong scientific background, having previously worked in the field of human disease genetics; Experience in RNA-seq data analysis; Experience in statistical data analysis; Great oral and written communication skills in Portuguese and English; First-authorship of at least one article published in a Q1 journal in the fields relevant to the project. Legislation and other applicable regulations : Research Fellowship Holder Statute enacted by Law no. 40/2004 of August 18th, as amended; FCT Research Grants Regulation, approved by way of Regulation nr. 950/2019, published in the II Series of DR of December 16th, 2019; i3S Research Grants Regulation. Place : The research activities will be hosted at i3S and ICBAS - School of Medicine and Biomedical Sciences, under the scientific coordination of Prof. Carolina Lemos. Length time: The duration of the fellowship is 4 months, and the expected starting date is September 1st, 2026, upon availability of the financed funds. Monthly maintenance stipend: €1.359,64, according to the values table of FCT, at Portugal ( https://www.fct.pt/wp-content/uploads/2026/03/Tabela-de-Valores-SMM-2026.pdf ). The payments will be made by bank transference. Research grants may also include other components, as the voluntary social insurance, under the terms of the Research Fello Annuncio in inglese. Fonte: Euraxess (Commissione europea).